Home > About us > Faculty > Hong In Shin Education  1988 Ph.D., Depart of Dentistry, The graduate school, Kyungpook National University  1985 M.S., Depart of Dentistry, The graduate school, Kyungpook National University  1983 B.S., Depart of Dentistry, School of Dentistry, Kyungpook National University Career  2007-present Chief, Institute for Hard tissue and Bio-tooth regeneration  2001-present Professor, Department of Oral Pathology, Kyungpook National University  1996-2001 Associate Professor, Department of Oral Pathology, Kyungpook National University  1992-1996 Assistant Professor, Department of Oral Pathology, Kyungpook National University  1989-1992 Full Time Lecturer, Department of Oral Pathology, Kyungpook National University  1998-2000 Research Fellow, Endocrine Unit, MGH, School of Medicine, Harvard University  1993-1994 Research Fellow, Endocrine Unit, MGH, School of Medicine, Harvard University Research Interests  Tissue engineered bone formation  Regeneration of bio-tooth  Bone tissue homeostasis Selected Publication  Secretome Analysis of Human BMSCs and Identification of SMOC1 as an Important ECM Protein in Osteoblast   Differentiation. J Proteome Res. 2010. [Epub ahead of print]  The Orphan Nuclear Receptor SHP is a Positive Regulator of Osteoblastic Bone Formation. J Bone Miner Res. 2010.   25(2):262-74.  Comparative Evaluation of Nanofibrous Scaffolding for Bone Regeneration in Critical-Size Calvarial Defects. Tissue   engineering. Part A 2009, 15(8):2155-2162  Enhanced Ex Vivo Expansion of Human Adipose Tissue-Derived Mesenchymal Stromal Cells by Fibroblast Growth   Factor-2 and Dexamethasone. Tissue engineering. Part A. 2009, 15(9):2491-9  Proteomics Analysis of Human Dentin Reveals Distinct Protein Expression Profiles. Journal of proteome research.   2009, 8(3):1338-1346  Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice. J Clin Invest.   2009, 119(4):813-25.  Proteomics analysis of human dentin reveals distinct protein expression profiles, J Proteome Res.   2009, 8(3):1338-46.  Comparative evaluation of nanofibrous scaffolding for bone regeneration in critical-size calvarial defects. Tissue Eng   Part A. 2009, 15(8):2155-62.  Epidermal growth factor receptor regulates osteoclast differentiation and survival through cross-talking with RANK   signaling, Journal of cellular physiology. 2008, 217(2):409-42.  Bone tissue formation in extraction sockets from sites with advanced periodontal disease: a histomorphometric   study in humans. Int J Oral Maxillofac Implants. 2008, 23(6):1133-38. Project  The optimum animal experimentation of dental Bone Substitutes - A variety of membrane materials has beendeveloped for guided bone regeneration (GBR) and guided tissue regeneration (GTR) We tested novel biocompatible and degradation-controlled of bone substitutes for the applications to periodontal barrier membranes. - After in vitro degradation tests in bone substisutes were assessed as periodontal barrier membranes for bone regeneration in the calvarial critical size bone defect rabbit. Histological and histomorphometric analyses were carried out after hematoxylin-eosin (H&E) staining of regenerated bones in 4 and 8 weeks.  Evaluation of bone regeneration efficacy of candidate chemical compounds - Evaluation of fracture healing efficacy of candidate chemical compounds - Evaluation of osteoblastic differentiation control of human bone marrow stromal cells (hBMSC) by chemical compounds - Evaluation of tooth formation efficacy of candidate chemical compounds    Tissue engineering study for Biotooth implantation - The purpose of this study was to estavlish fundamental technologies for   regeneration of bio-tooth. To achieve this purpose. We focused on   development of technologies related to potentiation of function of dental   and non-dental mesenchymal stem cells, and to production of materials   derived from humn tooth. - Therefore, we mainly studied on   1) characterization of differentiation characteristics of bone marrow       mesenchymal stem cells (BMSCs) and dental pulp stem cells (DPSCs)   2) genome-wide screening and validation of genes that fluctated during       differentiation of BmsCs and DPSCs   3) characterization of constituents extracted from tooth   4) preparation of scaffold derived from tooth   5) development of techniques for implantation of cell-scaffold composites       for in vivo tooth regeneration       Our results can be used for the regeneration of biotooth.